LatAm-FINGERS Initiative for Cognitive Change

Summary

Currently, 40% of global dementia cases can be prevented through lifestyle changes, with Latin America having a 56% potential reduction due to its high-risk factors. At the moment, there are no medications that halt the clinical expression of dementia.

LatAm-FINGERS, a multicenter study across 12 Latin American countries, aims to study the feasibility of an intervention modifying lifestyle in individuals aged 60 to 77 at risk of dementia. Success could influence public policy on clinical care for older adults.

Conditions

• Alzheimer Disease

Interventions

BEHAVIORAL

Systematic Lifestyle Intervention

Lifestyle intervention that involves providing participants with education, support, and tangible tools to assist them in developing and carrying out healthier lifestyle practices.

BEHAVIORAL

Flexible Lifestyle Intervention

Lifestyle intervention that involves a structured program of diet, physical and cognitive exercise, and management of cardiometabolic risks.

Sponsors & Collaborators

• Alzheimer's Association

  collaborator OTHER

• Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

  lead OTHER

Principal Investigators

• Ricardo Francisco Allegri, MD, Ph.D · Fleni Neurological Institute, Buenos Aires, Argentina

• Lucía Crivelli, Ph.D · Fleni Neurological Institute, Buenos Aires, Argentina

• Gustavo Emilio Sevlever, MD, Ph.D · Fleni Neurological Institute, Buenos Aires, Argentina

• María Isabel Cusicanqui, MD · Centro Neurológico Mente Activa, La Paz, Bolivia

• Ricardo Nitrini, MD, Ph.D · University of São Paulo School of Medicine, São Paulo, Brazil

• Paulo Caramelli, MD, Ph.D · Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

• Carolina Delgado Derio, MD, MSc · Hospital Clínico Universidad de Chile, Santiago, Chile

• Francisco Lopera, MD, Ph.D · Antioquia University, Colombia

• Jorge Mario Leon-Salas, MD · GBHI, TCD. Hospital Clínica Bíblica, San José, Costa Rica

• Lissette Duque-Peñailillo, MD · Neuromedicenter, Quito, Ecuador

• Ana Luisa Sosa, MD, Ph.D · Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México

• Nilton Custodio, MD, Ph.D · Instituto Peruano de Neurociencias, Lima, Perú

• Ivonne Z. Jiménez-Velázquez, MD · Universidad de Puerto Rico, San Juan, Puerto Rico

• Daisy Acosta, MD, Ph.D · Universidad Nacional Pedro Henriquez Urena (UNPHU), Santo Domingo, Dominican Republic

• Ana María Charamelo Baietti, Ph.D · Facultad de Medicina-Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay

• Ricardo Francisco Allegri, MD, Ph.D · Fleni Neurological Institute, Buenos Aires, Argentina

• Paulo Caramelli, MD, Ph.D · Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

• Francisco Lopera, MD, Ph.D · Antioquia University, Colombia

• Ricardo Nitrini, MD, Ph.D · University of São Paulo School of Medicine, São Paulo, Brazil

• Gustavo Emilio Sevlever, MD, Ph.D · Fleni Neurological Institute, Buenos Aires, Argentina

• Ana Luisa Sosa, MD, Ph.D · Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México

• Ismael Calandri, MD · Fleni Neurological Institute, Buenos Aires, Argentina

• Rosa María Salinas, MD, Ph.D · Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México

• Claudia Suemoto, MD, Ph.D · University of São Paulo Medical School, São Paulo, Brazil

• Lina Marcela Velilla, Ph.D · Antioquia University, Colombia

• Mônica Sanches Yassuda, Ph.D · University of São Paulo School of Medicine, São Paulo, Brazil

• Lucía Crivelli, Ph.D · Fleni Neurological Institute, Buenos Aires, Argentina

• Sonia Maria Dozzi Bruki, MD, Ph.D · University of São Paulo School of Medicine, São Paulo, Brazil

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

77 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-10-27

Primary Completion

2025-11-07

Completion

2025-11-07

Countries

• Argentina
• Bolivia
• Brazil
• Chile
• Colombia
• Costa Rica
• Dominican Republic
• Ecuador
• Mexico
• Peru
• Puerto Rico
• Uruguay

Study Locations