The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study

Summary

A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. The SINGER study is a 2-year randomized controlled trial that aims to test the efficacy and safety of these lifestyle changes, including diet and cardiovascular risk factor management, cognitive and physical exercises, in delaying cognitive decline in older adults at risk of dementia.

Conditions

• Cognitive Impairment
• Alzheimer Disease
• Vascular Cognitive Impairment
• Dementia
• Brain Diseases
• Central Nervous System Diseases
• Nervous System Diseases
• Neurocognitive Disorders
• Mental Disorders
• Cognition Disorder

Interventions

BEHAVIORAL

Structured Lifestyle Intervention

Structured Lifestyle Intervention (SLI) involves providing participants with intensive structure and support by a team of trainers to increase physical exercise, adhere to a healthy diet, cognitive training, increase intellectual/social stimulation, and better manage vascular risk factors.

BEHAVIORAL

Self-Guided Intervention

In the Self-Guided Intervention (SGI), education about the importance of a healthy lifestyle as a preventive strategy and support to encourage change will be provided.

Sponsors & Collaborators

• National Medical Research Council (NMRC), Singapore

  collaborator OTHER_GOV

• National University of Singapore

  lead OTHER

Principal Investigators

• Christopher LH Chen, MD · National University of Singapore

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

77 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-08-23

Primary Completion

2025-12-31

Completion

2026-01-31

Countries

• Singapore

Study Locations