Impact of Lifestyle Modification on the Development of Dementia, Chronic Kidney Disease, Diabetes, Chronic Obstructive Pulmonary Disease, Cancers and Cardiovascular Disease in a Thai General Population

Summary

This is a community-based cluster randomized control trial aimed to investigate the impact of lifestyle modification (diet, physical activity, alcohol drinking and smoking) on the development of dementia, diabetes, chronic kidney disease, cancers, chronic obstructive pulmonary disease and cardiovascular disease in an intermediate risk population in mixed urban-rural areas of Ubon Ratchathani.

Conditions

• Dementia
• Diabetes Mellitus
• Chronic Kidney Disease
• Cardiovascular Diseases
• Malignancy
• Chronic Obstructive Pulmonary Disease

Interventions

BEHAVIORAL

4 x 4 lifestyle modification

Participants in the intervention group will be given 4x4 lifestyle modification intervention, which will address four health behaviors (diet, physical activity, alcohol drinking and smoking) at four different levels: individual, household, knowledge management and community levels. A new computer program called 'iActive' adapted from the GPAQ with add-on functions to allow real-time assessment and presentation of the energy expenditure along with recommendations specific to each individual will be used. Dietary counseling will be given individually following assessment using a new dietary assessment program called Dietary Assessment Scanning Calculator. Home visit will be done every 3 months by responsible nurses and village health volunteers. Knowledge management will be done through meetings between participants and villages with support from trained nurses. Situation analysis and community action will be encouraged to address four health behaviors.

Sponsors & Collaborators

• Dementia Association of Thailand

  collaborator UNKNOWN

• Diabetes Association of Thailand

  collaborator UNKNOWN

• The Endocrine Society of Thailand

  collaborator OTHER

• Nephrology Society of Thailand

  collaborator UNKNOWN

• Thai Dietetic Society

  collaborator UNKNOWN

• Ubon Ratchathani Public Health Office, Thailand

  collaborator OTHER_GOV

• Sanpasitthiprasong Hospital

  lead OTHER_GOV

Principal Investigators

• Prasert Boongird, MD · Dementia Association of Dementia

• Parinya Chamnan, MD, PhD · Sanpasitthiprasong Hospital

• Wannee Nitiyanant, MD · Siriraj Hospital

• Wichai Aekplakorn, MD, PhD · Ramathibodi Hospital, Mahidol University

• Chanida Pachotikarn, PhD · Thai Dietetic Society

• Chaicharn Deerochanawong, MD · Rajvithi Hospital

• Surasak Kantachuvesiri, MD, PhD · Ramathibodi Hospital, Mahidol University

• Wallaya Jongjaroenprasert, MD · Ramathibodi Hospital, Mahidol University

• Atiporn Ingsathit, MD, PhD · Ramathibodi Hospital, Mahidol University

• Win Techakehakij, MD, PhD · Lampang Hospital

• Phanida Krittayapoositpot, MD · Dementia Association of Thailand

• Worawan Chailimpamontri, MD · Bhumibol Adulyadej Hospital

• Ampika Mangklabruks, MD · Faculty of Medicine, Chiangmai University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

45 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-03-31

Primary Completion

2027-03-31

Completion

2027-08-31

Countries

• Thailand