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U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk

NCT03688126 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2000

Last updated 2025-11-03

No results posted yet for this study

Summary

The purpose of this research study is to see if lifestyle changes can protect memory and thinking (cognition) as we age. A recent study in Finland found that a combination of physical and cognitive exercise, diet, and social activity protected cognitive function in healthy older adults who were at increased risk of significant memory loss. So far no medications can rival this positive outcome. The point of POINTER is to test if lifestyle change can also protect against memory loss in Americans.

Conditions

  • Alzheimer Disease

Interventions

BEHAVIORAL

Self-Guided Lifestyle Intervention

Lifestyle intervention that involves providing participants with education, support, and tangible tools to assist them in developing and carrying out healthier lifestyle practices.

BEHAVIORAL

Structured Lifestyle Intervention

Lifestyle intervention that involves a structured program of diet, physical and cognitive exercise, and management of cardiometabolic risks.

Sponsors & Collaborators

Principal Investigators

  • Laura D Baker, PhD · Wake Forest University Health Sciences

  • Mark A Espeland, PhD · Wake Forest University Health Sciences

  • Rachel A Whitmer, PhD · University of California, Davis

  • Miia Kivipelto, MD, PhD · Karolinska Institutet

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-08
Primary Completion
2025-05-16
Completion
2025-05-16

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03688126 on ClinicalTrials.gov