Dutch Multidomain Lifestyle Intervention in Older Adults at Risk of Cognitive Decline

Summary

FINGER-NL is a multi-center, randomized, controlled, multidomain lifestyle intervention trial among 1,206 older adults at risk for cognitive decline with a duration of 24 months. Participants are randomized in a 1:1 ratio to a personalized multi-domain lifestyle intervention (high-intensity intervention group) versus online access to general lifestyle-related health information (low-intensity intervention group). After the intervention period, participants are invited for a 24 month extension of follow-up.

Conditions

• Cognitive Decline
• Life Style
• Risk Reduction

Interventions

BEHAVIORAL

Multidomain lifestyle intervention

A multidomain lifestyle intervention, including (1) physical activity, (2) cognitive training, (3) cardiovascular risk factor management (Cardiovascular), (4) dietary counselling, (5) Souvenaid, (6) sleep counselling, (7) stress management, and (8) social activities.

Sponsors & Collaborators

• Maastricht University

  collaborator OTHER

• Radboud University Medical Center

  collaborator OTHER

• Wageningen University and Research

  collaborator OTHER

• University Medical Center Groningen

  collaborator OTHER

• Danone Nutricia Research

  collaborator INDUSTRY

• Alzheimercentrum Amsterdam

  lead OTHER

Principal Investigators

• Wiesje M van der Flier, Prof · Alzheimer Center Amsterdam

• Sebastian Köhler, Ass Prof · Maastricht University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

79 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-02-24

Primary Completion

2025-06-01

Completion

2027-06-01

Countries

• Netherlands

Study Locations