Alzheimer disease is a progressive neurodegenerative disorder and the most common cause of dementia, characterized by memory loss, cognitive decline, and functional impairment over time.
Two studies of older adults with type 2 diabetes linked diabetic retinal disease with higher dementia risk. DME and more severe diabetic retinopathy were associated with higher all-cause and vascular dementia risk, but not consistently with Alzheimer’s disease.
A study in Nature Medicine found that a single blood test model using plasma %p-tau217 can estimate when Alzheimer’s symptoms are likely to begin. In 603 patients, the model linked biomarker positivity with symptom onset, with a median error of 3.0 to 3.7 years.
January and March 2026 drug pipeline updates included Phase 3 results, Fast Track designations and Priority Review decisions across multiple disease areas. Mavacamten, teplizumab-mzwv, anifrolumab, AXS-05, gedatolisib and AFTX-201 were among the programs with notable milestones.
A Delphi consensus of 23 experts identified Zostavax, sildenafil and riluzole as high-priority candidates for Alzheimer disease clinical trials. Caregivers ranked the herpes zoster vaccine highest for acceptability and perceived benefit–risk balance.
New research demonstrates that blood tests measuring p-tau217 protein can identify dementia risk up to 25 years before symptoms and significantly improve diagnostic accuracy in clinical practice.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07602582 |
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT). |
NOT_YET_RECRUITING | PHASE3 |
| NCT07602283 |
Music for Pain and Dementia |
RECRUITING | NA |
| NCT07598370 |
A Study of LY3439539 in Participants With Alzheimer's Disease |
NOT_YET_RECRUITING | PHASE1 |
| NCT07572565 |
REPAIR Sleep Study |
NOT_YET_RECRUITING | NA |
| NCT07571161 |
Donanemab (LY3002813) Trial in Chinese Participants With Cognitively Unimpaired (Preclinical) Alzheimer's Disease |
NOT_YET_RECRUITING | PHASE3 |
| NCT07548073 |
Effect of Scene-Based Training on Cognitive Function in Patients With Alzheimer's Disease |
COMPLETED | NA |
| NCT07545473 |
Retinal Hyperspectral Imaging in Neurodegenerative Diseases |
RECRUITING | NA |
| NCT07543094 |
Efficacy and Safety of Temporal Interference Stimulation on Cognitive Function in Patients With Early-Stage Alzheimer's Disease |
ENROLLING_BY_INVITATION | NA |
| NCT07529912 |
Detecting Beta-amyloid in the Retina |
TERMINATED | NA |
| NCT07413744 |
The Gut - PRO Study |
NOT_YET_RECRUITING | PHASE2 |
