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Effect of Probiotic Supplements on Osteoarthritis Outcomes

NCT06459700 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 86

Last updated 2026-04-03

No results posted yet for this study

Summary

Dysbiosis of the gut microbiota is believed to contribute to the development and progression of osteoarthritis (OA), suggesting a role for probiotics in the treatment of OA. Animal studies have shown that certain probiotic strains decrease the inflammatory responses, pain sensitization and OA progression. There are, however, few clinical studies in humans to support this. In this double-blinded randomized controlled trial we will investigate the effect of 6-months probiotic supplements compared to placebo on OA related outcomes in females with diagnosed knee OA.

Conditions

Interventions

DIETARY_SUPPLEMENT

Probiotic supplements

See arm/group description

DIETARY_SUPPLEMENT

Placebo supplements

See arm/group description

Sponsors & Collaborators

  • Probi AB

    collaborator INDUSTRY

  • Lund University

    lead OTHER

Principal Investigators

  • Eva Ageberg · Lund University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2027-04-30
Completion
2027-04-30

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06459700 on ClinicalTrials.gov