Knee osteoarthritis is a degenerative joint disease that causes pain, swelling, and stiffness and can progressively impair mobility. It is the most commonly affected osteoarthritis site globally.
Five intra-articular gene therapy platforms for knee osteoarthritis are in human trials in the US, while India prepares regulatory guidelines for mRNA, gene and cell therapies to accelerate innovation.
Roche signed an agreement to invest $478 million in Korea clinical trials over five years, marking the largest foreign pharmaceutical investment. Korean companies are also securing pre-approval licensing deals globally, demonstrating growing competitiveness.
New research reveals semaglutide may directly repair cartilage in osteoarthritis patients, while a separate study raises concerns about SNAC, an ingredient used in oral semaglutide formulations, and its effects on gut health.
Eli Lilly is developing multiple next-generation obesity treatments, including oral GLP-1 drug orforglipron expected to launch in Q2 2026, as competition intensifies in a market projected to reach $95 billion by 2030.
GLP-1 weight loss drugs show increasing efficacy but raise concerns about excessive weight loss, side effects, and the rise of unregulated compounded versions sold online.
MEDIPOST has submitted an investigational new drug amendment to the FDA to initiate a Phase III trial of its umbilical cord blood-derived mesenchymal stem cell therapy for knee osteoarthritis, with patient enrollment expected in the first half of 2026.
Eli Lilly reported positive Phase 3 results for retatrutide showing up to 71.2 lbs average weight loss, while stockpiling $1.5 billion of oral drug orforglipron ahead of anticipated FDA approval in April 2026.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07603973 |
Effect of an Information- and Self-management App for People With Knee Osteoarthritis |
RECRUITING | NA |
| NCT07598474 |
Pregabalin Phonophoresis and MET for Knee Osteoarthritis |
RECRUITING | NA |
| NCT07583264 |
Early Weight Bearing After Open Wedge High Tibial Osteotomy (OWHTO), Is it Worth? |
ACTIVE_NOT_RECRUITING | NA |
| NCT07575555 |
The Effect of Lipedema on Knee Osteoarthritis |
NOT_YET_RECRUITING | |
| NCT07574775 |
Is It Possible to Obtain Reliable MPTA and LDFA Values Using Imageless Navigation in Total Knee Arthroplasty? Comparison Between Preoperative CT Scan Measurements and Intraoperative Bone Morphing Before and After Articular Cartilage Removal |
COMPLETED | NA |
| NCT07568691 |
Comparing Whole-Body Vibration vs. Balance Board Exercise for Pain, Function, and Quality of Life in Obese Adults With Knee Osteoarthritis |
COMPLETED | NA |
| NCT07565298 |
Adding Group-Based Pain Neuroscience Education to a Community Exercise Program for Older Women With Knee Osteoarthritis |
COMPLETED | NA |
| NCT07562646 |
Effects of Two Bar Knee Off-Load Brace With Non Weight Bearing Strength Training Among Knee Osteoarthritis Patients |
NOT_YET_RECRUITING | NA |
| NCT07556003 |
Effect of Physical Therapy Rehabilitation on Gait and Plantar Pressure in Patients After Total Knee Replacement |
RECRUITING | NA |
| NCT07553871 |
Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Arthroplasty |
NOT_YET_RECRUITING |
