Neural Mechanisms of Sensory Processing Anomalies

Summary

To assess sensory processing anomalies in neurotypical children, children with autism spectrum disorder, and attention-deficit hyperactivity disorder, particularly within the vibrotactile and auditory sensory modalities.

Conditions

• Attention Deficit Hyperactivity Disorder
• Autism Spectrum Disorder
• Sensory Processing Disorder

Interventions

BEHAVIORAL

Discrimination Acuity test

Estimating the just-noticeable difference of auditory loudness and vibrotactile displacement to fit a psychometric function for each modality with parameters: threshold, slope, sensitivity, and response criterion.

DIAGNOSTIC_TEST

Transiently Evoked Otoacoustic Emission

Examination of integrity of outer hair cells in the inner ear; with and without contralateral suppression.

OTHER

Questionnaires

Caregiver questionnaires send to parents online to acquire demographic information Autism Quotient (AQ), Child Behavior Checklist (CBCL6-16), Sensory Profile 2 (SP-2).

BEHAVIORAL

Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)

Estimates intelligence quotient

DIAGNOSTIC_TEST

Clinical tests of ASD

Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2)

OTHER

Electroencephalography (EEG) with auditory or vibrotactile stimuli

Two paradigms will be used: an auditory frequency tagging paradigm with interspersed pitch oddballs and a classical sensory gating paradigm with either vibrotactile stimuli or auditory clicks.

DIAGNOSTIC_TEST

Clinical tests of ADHD

ADHD-Rating Scale (ADHD-RS)

Sponsors & Collaborators

• North Denmark Region

  collaborator OTHER_GOV

• Aalborg University

  lead OTHER

Eligibility

Min Age

8 Years

Max Age

15 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-11-01

Primary Completion

2025-10-31

Completion

2025-10-31

Countries

• Denmark

Study Locations