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Neurophysiology of Surround Inhibition in the Human Motor Cortex

NCT03018262 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 53

Last updated 2023-11-24

No results posted yet for this study

Summary

Background:

Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement. They want to learn about which brain regions could be abnormal in people with movement disorders.

Objective:

To better understand how the brain controls movement.

Eligibility:

Healthy, right-handed adults age 18-70 years old.

Design:

Participants will be screened with a physical exam and questions about their handedness. They may have a urine test.

Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The second will last about 3 hours.

Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder.

Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain. Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position.

Participants will perform a simple index finger movement task.

Participants may have surface electromyography from at least two hand muscles. Small metal disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a comfortable chair with their hands placed on a pillow.

Participants may have an electroencephalography. A cap with small disc electrodes will be placed on the scalp.

Conditions

  • Normal Physiology

Interventions

DEVICE

TMS - sub-study 1

TMS pulses will be applied to the motor hotspot of the surround muscle to identify the TMS-evoked potentials corresponding to motor surround inhibition (SI)

DEVICE

TMS - sub-study 2

TMS will be used to stimulate the motor cortex and an inhibitory region of the inferior parietal lobe

DEVICE

TMS - sub-study 3

TMS pulses will be delivered to the primary motor cortex at rest, at the onset of the motor task, or during the motor task

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    lead NIH

Principal Investigators

  • Mark Hallett, M.D. · National Institute of Neurological Disorders and Stroke (NINDS)

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-07
Primary Completion
2021-03-24
Completion
2021-03-24
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03018262 on ClinicalTrials.gov