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Neural Correlates of Sensory Phenomena in Tourette Syndrome

NCT03914664 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-01-14

No results posted yet for this study

Summary

The most pervasive sensory manifestation of TS is sensory over-responsivity (SOR). SOR is defined as excessive behavioral response to commonplace environmental stimuli. SOR is an integral but poorly understood facet of the TS phenotype, one intertwined with core elements of the disorder and worse QOL. This proposal seeks to clarify the mechanistic bases of SOR in TS. Adults with with TS will be recruited 1) to complete a standardized clinical symptom assessment battery and 2) to undergo electroencephalogram (EEG), autonomic, and audio-visual monitoring during tactile and auditory stimuli paradigms, as well as at rest.

Conditions

Interventions

DIAGNOSTIC_TEST

Electroencephalogram (EEG) testing procedure

EEG testing procedure, comprised of somatosensory and auditory event-related potential paradigms, as well as resting state EEG

DIAGNOSTIC_TEST

Autonomic function testing procedure

Autonomic function testing procedure, comprised of electrodes to determine heart rate variability and electrodermal activity (EDA)

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-07-20
Primary Completion
2027-02-28
Completion
2027-02-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03914664 on ClinicalTrials.gov