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PGT-A Evaluates Advanced Sperm Selection in Embryos From High Teratozoospermia Males

NCT06231589 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 264

Last updated 2024-01-30

No results posted yet for this study

Summary

In this study of 264 couples, sperm selection techniques in males with high teratozoospermia index and sperm DNA fragmentation significantly increased fertilization, blastocyst development rates, and maintained comparable embryo euploidy rates through preimplantation genetic testing, suggesting the efficiency of these techniques in improving assisted reproductive outcomes.

Conditions

Interventions

DEVICE

Sperm Selection

Sperm selection using physiological intracytoplasmic sperm injection (PICSI dish) or magnetic-activated cell sorting (MACS) for selecting sperm with high-quality, better morphology and lower DNA fragmentation.

Sponsors & Collaborators

  • Ganin Fertility Center

    lead OTHER

Principal Investigators

  • Mohamed Nasreldin, MSc. · Ganin Fertility Center

  • Hanan Ramadan, PhD · Cairo University

  • Maiada Moustafa, PhD · Helwan University

  • Mohamed Abas, MBB · Cairo University

  • Hosam Zaki, MSc, FRCOG · Ganin Fertility Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2023-09-01
Completion
2023-09-01

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06231589 on ClinicalTrials.gov