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Testicular Tissue Cryopreservation for Fertility Preservation in Male Patients Facing Infertility-causing Diseases or Treatment Regimens

NCT02687880 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2019-07-12

No results posted yet for this study

Summary

Many chemotherapy and radiation-containing regimens for cancer or prior to bone marrow transplantation can cause sterility in children and young adults. In addition, some human disease conditions (e.g., Klinefelter's) are associated with infertility. Semen cryopreservation is available as a fertility-preserving option for post pubertal boys and adult men, but many do not take advantage of this option due in part to lack of information, illness, and/or time constraints relative to their treatment plan. Currently, no fertility-preserving options are available for prepubescent boys who are not yet producing sperm. The primary objective of the proposed study is to 1) Optimize techniques for cryopreserving testicular tissue, 2) Assess malignant contamination in testicular tissues and 3) develop methods to enrich spermatogonial stem cells and remove malignant contamination from testicular tissue. In addition, this study will process and cryopreserve tissue and/or cells for participating patients as a resource for future elective procedures to attempt fertility restoration.

Conditions

Interventions

PROCEDURE

Testicular biopsy

Subjects will undergo a surgical procedure to harvest their testicular tissue.

Sponsors & Collaborators

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Serena Dovey, MD · University of Colorado, Denver

Eligibility

Min Age
31 Days
Max Age
39 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-30
Primary Completion
2018-12-30
Completion
2018-12-30

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02687880 on ClinicalTrials.gov