Sperm Selection by Either PICSI or MACS in Cases With Abnormal Sperm DNA Fragmentation Index for ICSI

Summary

On the day of ICSI, choosing the best sperm by either PICSI or magnetic activated cell sorting (MACS) in cases with abnormal DNA is not fully investigated. This study helps in solving this problem by using two known techniques to achieve that purpose.

Conditions

• Sperm DNA Fragmentation

Interventions

OTHER

PICSI

sperm selection using PICSI dish for selecting sperm with lower DNA fragmentation index

OTHER

MACS

sperm selection using MACS for selecting sperm with lower DNA fragmentation index

Sponsors & Collaborators

• The Cleveland Clinic

  collaborator OTHER

• University of the Western Cape

  collaborator OTHER

• Ganin Fertility Center

  lead OTHER

Principal Investigators

• Hosam Zaki, MSc, FRCOG · Ganin Fertility Center, Cairo, Egypt

• Eman Hasanen, BSc · Ganin Fertility Center, Cairo, Egypt

• Khaled El Qusi, BSc · Ganin Fertility Center, Cairo, Egypt

• Abd El Ghafar Hussin, BSc · Ganin Fertility Center, Cairo, Egypt

• Salma El Tanbouly, BSc · Ganin Fertility Center, Cairo, Egypt

• Ashok Agarwal, PhD · American Center of Reproductive Medicine, Cleveland Clinic

• Ralph Henkel, PhD · University of the Western Cape

• Hanaa Alkhader · Ganin Fertility Center, Cairo, Egypt

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-01-01

Primary Completion

2019-03-30

Completion

2019-03-30

Countries

• Egypt

Study Locations