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Can the Origin of Sperm Affect Embryo Ploidy in Patients With Severe Male Factor Infertility?

NCT06476379 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-08-15

No results posted yet for this study

Summary

There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical outcomes following transfers of euploid embryos. This comparison will be conducted between cases where ejaculated sperm and cases where testicular sperm were used for intracytoplasmic sperm injection (ICSI), specifically focusing on severe male factor infertility patients.

Conditions

  • Male Infertility

Interventions

PROCEDURE

Testicular sperm extraction (TESE)

Surgical procedure used to retrieve sperm directly from the testicles of men who have low sperm production or no sperm in their ejaculate

OTHER

Ejaculate

Ejaculate processing for ICSI

Sponsors & Collaborators

  • Ganin Fertility Center

    lead OTHER

Principal Investigators

  • Eman Hasanen · Ganin Fertility Center

  • Hosam Zaki, FRCOG · Ganin Fertility Center

  • Refaat Gabre, PhD · Faculty of Science, Cairo University

  • Mohamed Abbas · Cairo University

  • Nahla Osama, Phd · Faculty of Science, Cairo University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-25
Primary Completion
2025-04-30
Completion
2025-04-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06476379 on ClinicalTrials.gov