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Acute Phase Response & Periodontal Treatment

NCT02460926 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2015-06-03

No results posted yet for this study

Summary

This study has compared quadrant scaling and root planing (Q-SRP) versus intensive treatment performed within 24 hours (FM-SRP) in terms of acute phase responses following treatment of periodontal disease. The primary aim was to compare the differences in CRP acute increase following FM-SRP versus Q-SRP therapy (24 hours after therapy). Secondary outcomes included changes in a broad array of inflammatory and endothelial injury markers between groups. Patients were randomly assigned to either FM-SRP and Q-SRP. Data indicated that non-surgical periodontal therapy performed within 24 hours induced greater perturbations of systemic inflammation compared to conventional treatment.

Conditions

  • Periodontal Diseases

Interventions

PROCEDURE

Scaling & Root Planing

It consists in the non-surgical debridement of the sub gingival area affected by periodontal disease

Sponsors & Collaborators

  • Eastman Dental Insitute and Hospital

    collaborator OTHER

  • University of Pisa

    lead OTHER

Principal Investigators

  • Filippo Graziani, DDS, PhD · University of Pisa

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-05-31
Primary Completion
2013-10-31
Completion
2014-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02460926 on ClinicalTrials.gov