MedTrace Logo

MTZ Plus AMX in the Treatment of Smokers and Non-smokers

NCT01837199 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2013-04-23

No results posted yet for this study

Summary

Randomized controlled clinical trials have demonstrated that the use of amoxicillin (AMX) and metronidazole (MTZ) as adjuncts to mechanical therapy improves the clinical and microbiological outcomes of scaling and root planing (SRP) in non-smokers and smokers with ChP. However, the effects of this antibiotic protocol have not been directly compared in non-smokers and smokers. Therefore, the aim of this study will be to compare the clinical and microbiological effects of the adjunctive use of MTZ+AMX to SRP in smokers and non-smokers subjects with chronic periodontitis (ChP). It was hypothesized that non-smokers would benefit better from this combination of therapies than the smokers.

Conditions

  • Chronic Periodontitis
  • Smoking

Interventions

DRUG

Metronidazole plus Amoxicillin

All subjects will receive scaling and root planing combined with systemic metronidazole (400 mg) and amoxicillin (500 mg). Both antibiotics were administered T.I.D. for 14 days.

Sponsors & Collaborators

  • University of Guarulhos

    lead OTHER

Principal Investigators

  • Marcelo Faveri, DDS, PhD. · University of Guarulhos

  • Magda Feres, DDS, PhD. · University of Guarulhos

  • Luciene C Figueiredo, DDS, PhD. · University of Guarulhos

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-07-31
Primary Completion
2012-12-31

Countries

  • Brazil

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01837199 on ClinicalTrials.gov