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Exercise and Galactooligosaccharide Supplementation on Inflammation and Iron Absorption (FexerGOS)

NCT06038656 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2025-03-13

No results posted yet for this study

Summary

Iron depletion is common in female athletes depending on the sports discipline. Endurance and resistance exercise can induce inflammation thereby reducing dietary iron absorption. Galacto-oligosaccharides (GOS) improved iron absorption in young healthy women and infants, and improved gut inflammation in iron-supplemented infants. A stable isotope study will be performed to investigate the effect exercise and acute and chronic GOS supplementation on inflammation and iron absorption in female athletes.

Conditions

  • Resistance Exercise

Interventions

DIETARY_SUPPLEMENT

Galactooligosaccharides (GOS)

10 g of GOS provided as 14 g of powder will be consumed after mixing it in water or yoghurt. The absorption study test drinks administered during the 3 test conditions will be comprised as follows: Post rest period - 50 mg of iron as ferrous fumarate (Fefum) supplement, 6 mg 54Fe as Fefum and 300 ml of water with sucrose and lactose. Post exercise bout - 50 mg of iron as Fefum, 6 mg 58Fe as Fefum and 300 ml of water with sucrose and lactose. Post exercise bout co-administered with GOS - 50 mg of iron as Fefum, 6 mg 57Fe as Fefum and 300 ml of water with 10 g GOS.

Sponsors & Collaborators

  • Swiss Federal Institute of Technology

    collaborator OTHER

  • King's College London

    collaborator OTHER

  • North-West University, South Africa

    lead OTHER

Principal Investigators

  • Isabelle Herter-Aeberli · ETH Zurich

  • Jesslee du Plessis · North-West University

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-03-01
Primary Completion
2024-11-19
Completion
2024-11-25

Countries

  • South Africa

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06038656 on ClinicalTrials.gov