The Effect of Probiotics and Vitamin D Supplementation on Sport Performance in MMA Athletes.

Summary

The probiotics supplementation seems to be safety way to optimize the intestinal microbiota composition and thus modulate the immune system and reduce oxidative stress. Moreover it may enhance muscle protein synthesis, mitochondrial biogenesis and function, as well as muscle glycogen storage. Probiotics intake via reduce inflammatory markers and reactive oxygen species production may attenuate macromolecules damage and have some beneficial effect on aerobic and anaerobic performance. The combined probiotics and vitamin D supplementation may enhance this effect. The synergistic intestinal microbiota and vitamin D interaction towards muscle protein synthesis and mitochondrial function improvement may be manifested by mTOR and FOXO signaling influence on oxidative stress as well as immunological functions modulation. In the study investigators will assess if multistrain probiotic mixture in conjunction with vitamin D may have beneficial effect on sport performance among trained male mixed-martial arts athletes. The study protocol is designed as a randomized double-blind placebo-controlled clinical trial. Researchers are going to evaluate changes in the gut, including microbiome composition and epithelial permeability; differences in the blood parameters as well as direct influence on sport performance, expressed by anaerobic and aerobic fitness capacity. Researchers will provide an evidences, having both theoretical as well as practical aspect.

Conditions

• Gut Microbiome
• Sport Performance

Interventions

COMBINATION_PRODUCT

Probiotic and vitamin D

Participants enrolled to PRO + D group will receive probiotics and vitamin D supplements as a intervention product. Participants enrolled to probiotic group will receive probiotics as well as vitamin D supplements.

DIETARY_SUPPLEMENT

placebo and vitamin D

Participants enrolled to PL+D group will receive vitamin D. Additionally they will get placebo instead of probiotics.

Sponsors & Collaborators

• Gdansk University of Physical Education and Sport

  collaborator OTHER

• Pomeranian Medical University Szczecin

  collaborator OTHER

• Medical University of Gdansk

  lead OTHER

Principal Investigators

• Katarzyna KP Przewłócka, MSc · Medical University of Gdańsk, Gdańsk, Poland

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-12-01

Primary Completion

2021-02-28

Completion

2021-03-31

Countries

• Poland

Study Locations