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The Combined Effects of Resistance Training and Flax Oil Supplementation Upon Inflammation in Older Adults

NCT00465153 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2007-11-05

No results posted yet for this study

Summary

Loss of muscle mass and functional ability is a major concern for older individuals. Aging is associated with increased inflammation caused by release of hormone-like compounds termed "cytokines" which are involved in muscle protein degradation. Diets rich in ω-3 fatty acids decrease the production of pro-inflammatory cytokines, possibly by inhibiting production of lipids involved in cytokine synthesis. Our purpose is to assess the effect of dietary supplementation with an ω-3 fatty acid, α-linolenic acid (ALA) commonly found in flaxseed, combined with resistance training on pro-inflammatory cytokines, strength, and muscle mass in older adults. Progressive resistance training is considered to be the standard for increasing strength and muscle mass in older adults. We hypothesize that combining the two interventions will improve strength and muscle mass more than resistance training alone by modulating the inflammatory process associated with aging. Our proposed research will compare older individuals supplementing with ALA and placebo during a resistance training program.

Conditions

Interventions

DIETARY_SUPPLEMENT

flax oil containing alpha linolenic acid

14g alpha linolenic acid per day

BEHAVIORAL

Resistance exercise training

Resistance training

Sponsors & Collaborators

  • Gatorade Sports and Science Institute

    collaborator OTHER

  • University of Saskatchewan

    lead OTHER

Principal Investigators

  • Philip D Chilibeck, Ph.D. · University of Saskatchewan

  • Lisa Paus-Jenssen, M.D. · University of Saskatchewan

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-04-30
Completion
2007-08-31

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00465153 on ClinicalTrials.gov