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Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies

NCT05995821 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1250

Last updated 2026-01-29

No results posted yet for this study

Summary

This research is being done to collect and store biological specimens (biospecimens) from people with cancer, regardless of tumor type, who are receiving treatments known or thought to have an effect on the immune system.

The goal of this discovery and exploratory study is to:

* Understand changes in the immune system associated with various cancer treatments, in order to better design new therapies or tests to predict how these treatments might work.
* Identify risk factors for those who go on to develop side effects from immunotherapy.
* Identify the molecular features associated with response and resistance to cancer therapies and immunotherapy using integrative genomic and immune repertoire characterization.
* Capture and characterize systemic tumor burden by minimally invasive analyses of circulating tumor DNA.

Participants may be asked to:

* Donate samples of tumor, blood, lymph nodes, white blood cells, mouth cells (buccal smears) scraped from the inside of participant's cheek, urine, saliva, or other tissue samples.
* Complete questionnaires about immunotherapy side effects at baseline and with follow-up appointments.
* Undergo knee x-rays.
* Allow the use of demographic and clinical information.

Conditions

Interventions

OTHER

Collection of biological specimens

Collection of tumor, blood, lymph nodes, white blood cells, mouth cells (buccal smears) scraped from the inside of your cheek, urine, saliva, or other tissue samples.

Sponsors & Collaborators

  • Stand Up To Cancer

    collaborator OTHER

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    lead OTHER

Principal Investigators

  • Valsamo Anagnostou, MD, PhD · Johns Hopkins University

  • Joseph Murray, MD · Johns Hopkins University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-25
Primary Completion
2026-08-25
Completion
2026-08-25

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05995821 on ClinicalTrials.gov