Head and Neck Cancer

Disease

Also known as: oral head and neck cancer

Related News

CEL-SCI to Begin U.S. Registration Study for Multikine in Summer 2026, Pursues Saudi Partnership

CEL-SCI plans to start patient enrollment in summer 2026 for a 212-patient U.S. registration study of its cancer immunotherapy Multikine, with the goal of seeking early accelerated approval. The company is also advancing a strategic partnership with Saudi Amarox to commercialize Multikine in Saudi Arabia, where it has submitted a Breakthrough Medicine Designation application. These initiatives build on Phase 3 data showing Multikine improved 5-year survival in head and neck cancer patients from 45% to 73%.

Structural Nanomedicine Vaccine Shows Promise Against HPV-Driven Cancers in Preclinical Study

A novel therapeutic vaccine using structural nanomedicine principles has shown promising results against HPV-driven cancers in preclinical models. The spherical nucleic acid vaccine design significantly slowed tumor growth and extended survival by generating potent T-cell responses. Unlike preventive HPV vaccines, this approach is designed to treat established cancers caused by the virus.

Immunotherapy Expands to Earlier Cancer Stages Across Multiple Tumor Types

Immunotherapy is increasingly used in earlier cancer stages before or after surgery across seven tumor areas. Research shows neoadjuvant and adjuvant immunotherapy can reduce recurrence risk and improve immune recognition of tumor cells. However, challenges remain including side effects, costs, and determining which patients benefit most from earlier treatment.

Related Clinical Trials

NCT ID Title Status Phase
NCT07613723

A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

RECRUITING PHASE1
NCT07583914

Safety, Tolerability, and Preliminary Antitumor Activity of Non-Cationic Peptide-CD47 siRNA in Advanced Solid Tumors

NOT_YET_RECRUITING PHASE1
NCT07583316

A Phase 1 First-in-Human Study of CRPA1A2, a MAGE-A1/HLA-A*02:01 Bispecific T-Cell Engager, in Patients With Solid Tumors

NOT_YET_RECRUITING PHASE1
NCT07558447

Extracellular Vesicles and Chemotherapy-Induced Peripheral Neuropathy

RECRUITING NA
NCT07557225

18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors

RECRUITING NA
NCT07556367

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

ACTIVE_NOT_RECRUITING NA
NCT07550049

Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology

NOT_YET_RECRUITING
NCT07532538

A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions

NOT_YET_RECRUITING
NCT07528495

A Trial Evaluating Omission of Radiotherapy to Regional Lymphatic's

RECRUITING PHASE2/PHASE3
NCT07524894

Staph Nasal Decolonization to Improve Function and Feeding

NOT_YET_RECRUITING PHASE2