A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
NCT00571389 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1500
Last updated 2026-03-18
Summary
Primary Objective:
This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers. The preliminary objective of this study is aimed at selecting PD-1+ and CTLA4+ T cells and other cellular fractions from peripheral blood of cancer patients and healthy volunteers by using specific conjugated antibodies, evaluating their functional ex vivo anti-tumor cytotoxicity against targeted autologous tumor cells.
Conditions
- Solid Tumor, Adult
- Healthy Donors
- COVID-19 Donors
Sponsors & Collaborators
-
BioCytics, Inc.
lead INDUSTRY
Eligibility
- Min Age
- 5 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2007-11-30
- Primary Completion
- 2030-02-28
- Completion
- 2030-02-28
Countries
- United States
Study Locations
More Related Trials
-
Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers
NCT03207854 ·Status: RECRUITING
-
Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients
NCT05164016 ·Status: COMPLETED
-
A Phase 1 Study of MEDI0562 in Adult Subjects With Selected Advanced Solid Tumors
NCT02318394 ·Status: COMPLETED ·Phase: PHASE1
-
Biological Therapy in Treating Patients With Advanced Cancer
NCT00005956 ·Status: COMPLETED ·Phase: NA
-
Long-Term Follow-up Study of Subjects Treated With Autologous T Cells Using the Sleeping Beauty System to Express TCRs
NCT05292859 ·Status: COMPLETED
-
Immune-Related Adverse Events and Associated Biomarkers in Patients Receiving Cancer Immunotherapy
NCT06089967 ·Status: COMPLETED
-
Personalized TCR-T: Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)
NCT05349890 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Immunity to Infection in Healthy Participants and Participants With Cancer
NCT05787964 ·Status: ACTIVE_NOT_RECRUITING
-
Neoantigen-expanded Autologous Immune Cell Therapy
NCT05020119 ·Status: UNKNOWN ·Phase: PHASE1
-
Autologous Antigen-activated Dendritic Cells in the Treatment of Patients With Breast Cancer
NCT03113019 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
CD30 CAR for CD30+ NSGCT
NCT05634785 ·Status: COMPLETED ·Phase: PHASE2
-
DLL3-Directed Chimeric Antigen Receptor T-cells in Subjects With Extensive Stage Small Cell Lung Cancer
NCT05680922 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus
NCT02479698 ·Status: RECRUITING ·Phase: PHASE2
-
Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma
NCT03035331 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
An Experimental Medicine Clinical Study to Compare Peripheral Immune System From Subjects Without Cancer Diagnosis and Patients With Solid Tumours.
NCT05133128 ·Status: TERMINATED ·Phase: NA
-
Hotspot TCR-T: A Phase I/Ib Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)
NCT04520711 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Exploration of Adaptive Antitumoral Immune Cells Through Lymphapheresis in Cancer Patients : ALCYTA
NCT05354765 ·Status: RECRUITING ·Phase: NA
-
Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer
NCT05620342 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Vaccine Therapy With or Without Cryosurgery in Treating Patients With Residual, Relapsed, or Refractory B-Cell Non-Hodgkin Lymphoma
NCT01239875 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
NCT05995821 ·Status: RECRUITING
-
Specialized Immune Cells (nCTLs) and a Vaccine (Alpha-type-1 Polarized Dendritic Cells) in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
NCT03735589 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Exploring Relevant Immune-based Biomarkers and Circulating Tumor Cells During Treatment With Immunotherapy in Genitourinary Malignancies (CTC Immune Based Biomarkers)
NCT02978118 ·Status: ACTIVE_NOT_RECRUITING
-
PBMC Collection for Production of UCAR T Cells
NCT04963959 ·Status: UNKNOWN ·Phase: NA
-
A Long Term Follow-up Study of TScan TCR-T Products
NCT06976736 ·Status: RECRUITING
-
Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy
NCT02821806 ·Status: RECRUITING