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Treatment With Endovascular Intervention for STroke Patients With Existing Disability

NCT05911568 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1060

Last updated 2026-04-15

No results posted yet for this study

Summary

TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.

Conditions

  • Stroke
  • Stroke, Acute
  • Stroke, Ischemic

Interventions

PROCEDURE

Endovascular Stroke Treatment

Patients who receive endovascular stroke treatment when they are admitted into the hospital, as determined by their clinical care team. Endovascular stroke treatment consist of catheter-based treatment for the blood clot causing the acute ischemic stroke

OTHER

Medical Management

Patients who receive MMM when they are admitted into the hospital, as determined by their clinical care team. MMM may involve any combination of the following: intravenous thrombolysis, antiplatelets, anti-hypertensives, cholesterol-lowering medications, and rehabilitative care. Specifically, this treatment does not involve endovascular stroke treatment.

Sponsors & Collaborators

Principal Investigators

  • Eva Mistry, MD · University of Cincinnati

  • Jeffrey Saver, MD · Ronald Reagan UCLA Medical Center

  • J Mocco, MD · Icahn School of Medicine at Mount Sinai

  • Heidi Sucharew, PhD · University of Cincinnati

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-16
Primary Completion
2028-01-15
Completion
2028-04-15

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05911568 on ClinicalTrials.gov