Randomization of Endovascular Treatment in Acute Ischemic Stroke in the Extended Time Window

Summary

A phase III, randomized, multi-center, open label clinical trial that will examine whether endovascular treatment is superior to standard medical therapy alone in patients who suffer a large vessel anterior circulation ischemic stroke within 8-24 hours from time last seen well

Conditions

• Stroke, Ischemic

Interventions

DEVICE

Thrombectomy

Endovascular treatment of large vessel occlusion (mechanical thrombectomy) with stent-retriever and/or thromboaspiration (neurointerventionalist choice)

Sponsors & Collaborators

• Hospital das Clínicas de Ribeirão Preto

  collaborator OTHER

• Hospital Geral de Fortaleza

  collaborator OTHER_GOV

• Hospital de Base

  collaborator OTHER

• Federal University of São Paulo

  collaborator OTHER

• Fundação Faculdade Regional de Medicina de São José do Rio Preto

  collaborator OTHER

• UPECLIN HC FM Botucatu Unesp

  collaborator OTHER

• University of Campinas, Brazil

  collaborator OTHER

• Irmandade Santa Casa de Misericórdia de Porto Alegre

  collaborator OTHER

• Universidade Federal do Paraná

  collaborator OTHER

• Hospital Estadual Central

  collaborator UNKNOWN

• Hospital Sao Jose do Avai

  collaborator UNKNOWN

• Irmandade da Santa Casa de Misericordia de Sao Paulo

  collaborator OTHER

• Federal University of Uberlandia

  collaborator OTHER

• Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo

  collaborator OTHER

• Hospital de Clinicas de Porto Alegre

  lead OTHER

Principal Investigators

• Raul G Nogueira, MD · Emory University

• Sheila CO Martins, MD, PhD · Hospital de Clinicas de Porto Alegre

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-03-09

Primary Completion

2022-02-01

Completion

2022-05-01

Countries

• Brazil

Study Locations