Also known as: UCLA
A phase II trial of TAK-007 CAR-NK therapy in R/R B-cell NHL showed a 60.9% overall response rate. Preclinical CAR-NKT therapy eliminated endometrial tumors in models. Optimized costimulatory domains (2B4-DAP12) boosted CAR-NK tumor killing.
Researchers developed a lipid nanoparticle gene-editing approach that inserted a full CFTR gene into airway cells and restored 88% to 100% of normal channel function in a cystic fibrosis lab model.
Three new CRISPR-based therapies show promise for treating heart failure through mitochondrial enhancement, cystic fibrosis via lipid nanoparticle gene insertion, and elevated cholesterol with single-dose gene editing targeting ANGPTL3.
UCLA scientists developed a lipid nanoparticle-based gene editing system that successfully inserts a full-length healthy CFTR gene into human airway cells, offering potential treatment for cystic fibrosis patients unresponsive to current therapies.
A UCLA clinical trial found that adding immunotherapy to chemotherapy before surgery is safe for borderline-resectable pancreatic cancer patients, with a subset experiencing deep, durable responses including complete tumor regression.
UCLA researchers developed lipid nanoparticle-based gene editing that inserts a complete CFTR gene into human airway cells, restoring up to 100% of normal channel function in cystic fibrosis laboratory models without viral vectors.
Trethera Corporation completed Phase 1 solid tumor dose escalation trial for TRE-515 and received FDA Fast Track designation for prostate cancer and Orphan Drug status for two autoimmune neurologic diseases.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07600697 |
Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery |
NOT_YET_RECRUITING | PHASE4 |
| NCT07599592 |
Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor |
RECRUITING | EARLY_PHASE1 |
| NCT07581327 |
Data-Driven Lay First Responder Program in Cameroon |
NOT_YET_RECRUITING | NA |
| NCT07577947 |
Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study |
NOT_YET_RECRUITING | NA |
| NCT07577401 |
Calming Minds Study |
NOT_YET_RECRUITING | NA |
| NCT07568119 |
Feasibility and Acceptance of SonoHeal for Airway Clearance and Preliminary Comparison With the Standard of Care |
ACTIVE_NOT_RECRUITING | |
| NCT07566104 |
Group PACBT for Depression |
NOT_YET_RECRUITING | PHASE2 |
| NCT07534696 |
Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy |
NOT_YET_RECRUITING | NA |
| NCT07510256 |
Effects of Breathwork and Meditation on Addiction Recovery |
COMPLETED | NA |
| NCT07495059 |
Adaptation and Implementation of an Evidence-based Approach to Advance HIV Prevention and Care |
RECRUITING | NA |
