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Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge Drink

NCT05882214 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2025-04-10

No results posted yet for this study

Summary

The goal of this double-blinded, randomized, crossover trial is to investigate the effects of NMN supplementation on liver function, liver fat content and lipid metabolism in healthy young subjects with acute binge drink. The main questions it aims to answer are:

1. if NMN administration could accelerate alcohol metabolism and alleviate hangover symptom;
2. if NMN administration could alleviate alcohol-induced liver injury and hepatic steatosis.

Conditions

  • Binge Drinking
  • Liver Injury
  • Nutritional Supplementation
  • Hepatic Steatosis

Interventions

DIETARY_SUPPLEMENT

β-nicotinamide Mononucleotide

After an 8-hour overnight fast, the participants ingested β-nicotinamide Mononucleotide capsules with a single morning dose of 1000mg. The purity of β-nicotinamide Mononucleotide capsules was no less than 97% according to high-performance liquid chromatography analysis.

DIETARY_SUPPLEMENT

Maltodextrin

After an 8-hour overnight fast, the participants ingested maltodextrin capsules with a single morning dose of 1000mg.

Sponsors & Collaborators

  • Zhejiang Chinese Medical University

    lead OTHER_GOV

Principal Investigators

  • Jiaomei Li · Zhejiang Chinese Medical University

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-01
Primary Completion
2025-02-18
Completion
2025-04-06

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05882214 on ClinicalTrials.gov