Impact of Yo-Yo Sleep on Cardiometabolic Health

Summary

The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).

Conditions

• Cardiometabolic Syndrome
• Obesity

Interventions

BEHAVIORAL

Intermittent Short Sleep (ISS)

Restricted sleep duration of \<5.5 h/night for 5 nights (SR) followed by 2 nights of 9.5 hours of time in bed (TIB) (recover sleep) each week.

BEHAVIORAL

Social Jetlag (SJL)

2-hour delayed sleep timing.

BEHAVIORAL

Sustained Adequate Sleep (SAS)

Goal of ≥7 hours of sleep/night with 8 hours of time in bed (TIB).

Sponsors & Collaborators

• Icahn School of Medicine at Mount Sinai

  collaborator OTHER

• University of Colorado, Denver

  collaborator OTHER

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Columbia University

  lead OTHER

Principal Investigators

• Marie-Pierre St-Onge, PhD · Columbia University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

49 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-09-22

Primary Completion

2027-12-31

Completion

2028-06-30

Countries

• United States

Study Locations