Biological Sample Repository for Gastrointestinal Disorders

Summary

The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients presenting with short- and long-term surgical complications. The aim is to enhance the overall understanding of the mechanisms leading to obesity, weight loss, failure to lose weight, and weight regain following treatment. Additional goals are to determine the efficacy of endoscopic and surgical procedures, to identify potential therapeutic targets and disease biomarkers that predict response to therapy.

Conditions

• Obesity
• Obesity, Morbid
• Obesity, Primary
• Gastro-Intestinal Disorder
• Overweight and Obesity
• Overweight
• Overweight or Obesity
• Diabetes Type 2
• Diabetes Mellitus
• Diabetes Mellitus, Type 2
• Hypertension
• Hyperlipidemias
• Sleep Apnea
• GERD
• Gastroesophageal Reflux
• Musculoskeletal Pain Disorder
• Cancer

Interventions

DIAGNOSTIC_TEST

Blood Collection

Blood collection via venipuncture

DIAGNOSTIC_TEST

Urine Collection

Free catch urine sample collection

DIAGNOSTIC_TEST

Tissue Sample Collection

Tissue (gastric, duodenum, jejunum and ileum - number of biopsies will be 3-4 from each site, ranging in size from 4-7mm) - These samples collected will be extra biopsies that are taken for research purposes during a clinically planned endoscopy for which biopsies are being planned.

Sponsors & Collaborators

• Tufts University

  collaborator OTHER

• Boston Children's Hospital

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• Pichamol Jirapinyo, MD, MPH

  lead OTHER

Principal Investigators

• Pichamol Jirapinyo, MD, MPH · Brigham and Women's Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-07-19

Primary Completion

2028-07-31

Completion

2029-04-30

Countries

• United States

Study Locations