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Metabolomic Fingerprint After Bariatric Surgery

NCT02480322 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 106

Last updated 2015-06-25

No results posted yet for this study

Summary

Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity.

Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood.

Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.

Conditions

Interventions

PROCEDURE

bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)

Sponsors & Collaborators

  • University of Florence

    collaborator OTHER

  • FiorGen Foundation, Italy

    collaborator UNKNOWN

  • eSwiss Medical & Surgical Center

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-05-31
Primary Completion
2012-05-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02480322 on ClinicalTrials.gov