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Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring

NCT05774561 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 480

Last updated 2026-02-12

No results posted yet for this study

Summary

This trial will evaluate the possible benefits and the performance of liquid biopsies in HPV-associated cancer treatment monitoring. This study aims to find a combination of an adequately sensitive and specific sampling method and biomarkers for early risk stratification of disease recurrence.

Conditions

  • Cervical Cancer
  • Cervical Dysplasia
  • Oropharyngeal Cancer
  • Human Papillomavirus Infection

Interventions

DIAGNOSTIC_TEST

Arm A - Diagnostic test: HPV detection in liquid biopsies

Patients will be asked to perform self-collection of gargle lavage samples. Oropharyngeal swabs, breath condensate, and blood samples will be taken by trained clinicians.

DIAGNOSTIC_TEST

Arm B - Diagnostic test: HPV detection in liquid biopsies

Patients will be asked to perform cervicovaginal self-sampling using Evalyn Brush. Blood samples will be taken by trained clinicians.

Sponsors & Collaborators

  • National Institute for Cancer Research, Czech Republic

    collaborator OTHER

  • University Hospital Olomouc

    collaborator OTHER

  • The Institute of Molecular and Translational Medicine, Czech Republic

    lead OTHER

Principal Investigators

  • Marian Hajduch, MD., PhD. · IMTM, Palacky University in Olomouc, Faculty of Medicine and Dentistry

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2026-05-31
Completion
2026-12-01

Countries

  • Czechia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05774561 on ClinicalTrials.gov