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Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer

NCT06362421 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2025-07-31

No results posted yet for this study

Summary

The purpose of this research study is to determine if saliva and oral swab samples can be used to detect human papillomavirus in patients with cancer. In this study, the methods required to detect human papillomavirus will be developed and tested in samples collected from patients with oropharyngeal squamous cell carcinoma and compared to samples collected from participants without cancer.

Conditions

  • Oropharyngeal Squamous Cell Carcinoma
  • Human Papillomavirus Infection

Interventions

GENETIC

Pre-Radiation Dental Evaluation/Sample Collection

Collection of saliva samples and mouth swabs and pre-cancer dental evaluation by study staff. Unstimulated saliva will be collected then a buccal swab sample will be obtained. Participants will be asked to rinse their mouth with water, wait 10 minutes, then 1-2 mL of unstimulated saliva will be captured into sterile centrifuge tube. Next, a buccal swab sample will be collected using a sterile cotton swab and immediately placed in a transport tube containing buffer (Tris with low EDTA)

OTHER

Pre-Study Visit

Collection of vital signs, medical history and current medications

GENETIC

Oral Medicine Consultation Visit/Sample Collection

Collection of saliva samples and mouth swab, complete oral medicine consultation by study staff. Unstimulated saliva will be collected then a buccal swab sample will be obtained. Participants will be asked to rinse their mouth with water, wait 10 minutes, then 1-2 mL of unstimulated saliva will be captured into sterile centrifuge tube. Next, a buccal swab sample will be collected using a sterile cotton swab and immediately placed in a transport tube containing buffer (Tris with low EDTA)

Sponsors & Collaborators

  • InnoTech Precision Medicine

    collaborator UNKNOWN

  • Wake Forest University Health Sciences

    lead OTHER

Eligibility

Min Age
39 Years
Max Age
59 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-31
Primary Completion
2026-08-31
Completion
2026-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06362421 on ClinicalTrials.gov