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Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?

NCT06592716 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-11-18

No results posted yet for this study

Summary

This study investigates if longitudinal analyses of cell-free HPV-DNA in blood samples can be utilized to detect recurrence in patients diagnosed and treated for HPV-positive oropharyngeal squamous cell carcinoma.

Conditions

  • Oropharynx Cancer
  • Oropharynx Cancer, Metastatic
  • Oropharynx Cancer, Recurrent
  • Oropharyngeal Carcinoma
  • Oropharyngeal Squamous Cell Carcinoma (OPSCC)

Interventions

DIAGNOSTIC_TEST

Liquid biopsy

The intervention is a liquid biopsy as a blood sample taken in a peripheral vein. The blood samples are analyzed for ctHPV-DNA.

Sponsors & Collaborators

  • Copenhagen University Hospital, Denmark

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Christian von Buchwald, Professor, MD, DMSci · Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-02
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06592716 on ClinicalTrials.gov