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Human Papillomavirus (HPV) and Risk of Cervical Precancer and Cancer

NCT00435214 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 131110

Last updated 2020-05-01

No results posted yet for this study

Summary

Background:

* In most women, HPV infection does not cause symptoms and the infection goes away on its own. In a small percentage of women, the HPV infection does not go away and sometimes can result in cervical precancer or cancer.
* There are several different types of HPV. A better understanding of which types are related to cervical precancer and cancer may help guide doctors in clinical management of women who test positive for HPV and better understand why some women develop disease while others do not.

Objectives:

* To determine whether certain types of HPV are more risky than others and if so, whether they warrant separate detection in screening for cervical precancer and cancer.
* To determine if lasting infection by different HPV types carry different risk of cervical precancer and cancer.
* To determine what viral and genetic factors influence the development of cervical precancer and cancer.
* To evaluate new HPV tests and new biomarkers of cervical cancer risk.

Eligibility:

-Women 30 years of age and older who are in the cervical cancer screening program at the Kaiser Permanente health plan in Northern California. Women who tested positive for HPV and a random sample of women who tested negative for the virus are included.

Design:

-Data about participants genetic background and the type of carcinogenic HPV with which they are infected are analyzed.

Conditions

  • Cervical Neoplasia

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    lead NIH

Principal Investigators

  • Mark H Schiffman, M.D. · National Cancer Institute (NCI)

Eligibility

Min Age
21 Years
Max Age
100 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-29
Primary Completion
2020-04-01
Completion
2020-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00435214 on ClinicalTrials.gov