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Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening

NCT07033091 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20000

Last updated 2026-02-13

No results posted yet for this study

Summary

This study defines the prevalence of oral infection with high-risk human papillomaviruses (hrHPV) in individuals over 40 years of age in the Czech Republic. It also establishes an effective methodology for oropharyngeal carcinoma screening and optimization of screening and testing procedures.

Conditions

  • Oropharynx Cancer

Interventions

DIAGNOSTIC_TEST

Self-sampling by gargling kit at dental clinic

Participants will perform a self-sampling at the dental clinic using gargling kit

OTHER

Questionnaire

Participants will answer questionnaire online/paper at their home or at the dental clinic

DIAGNOSTIC_TEST

Self-sampling by gargling kit at home

Participants will perform a self-sampling at home using gargling kit

DIAGNOSTIC_TEST

Blood sampling

Venous blood will be collected from study participants with oral hrHPV positivity, in which the presence of circulating hrHPV DNA will be determined.

DIAGNOSTIC_TEST

Self-sampling of the urogenital area

In case of a positive examination in the oropharynx, the tested individuals will be offered a self-collection HPV examination in the urogenital area (cervicovaginal swab in women or external genital swab in men).

Sponsors & Collaborators

  • National Institute for Cancer Research, Czech Republic

    collaborator OTHER

  • The Institute of Molecular and Translational Medicine, Czech Republic

    lead OTHER

Principal Investigators

  • Marian Hajduch, Ph.D. · Faculty of Medicine and Dentistry, Palacky University, Olomouc

Study Design

Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2030-12-31
Completion
2031-03-30

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07033091 on ClinicalTrials.gov