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Interaction Between Hypertension and Periodontitis

NCT05741970 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2023-02-23

No results posted yet for this study

Summary

Objective:The possible association between hypertension and periodontitis and the effect of hypertension on periodontal treatment were investigated by evaluating salivary and gingival crevicular fluid (GCF) interleukin (IL)-6 and C reactive protein (CRP) levels. Methods:Forty two healthy individuals without any previously diagnosed systemic disease \[10 periodontally healthy (control) and 10 periodontitis (CP)\] and subjects with hypertension \[13 periodontally healthy (HP) and 9 with periodontitis (CP + HP)\] participated in the study. GCF and saliva samples were obtained at baseline and four weeks after Phase I periodontal treatment. Biochemical parameters were analyzed using ELISA. Results:Before the periodontal treatment, significantly higher GCF IL-6 and CRP levels were detected in CP+HP and CP groups compared to HP and control groups (p\<0.01). Salivary CRP level in CP+HP group was found to be higher than the control group (p\<0.05). Statistically significant gingival and plaque index measurements (p\<0.01) might suggest a possible effect of hypertension on periodontal status. Periodontal treatment significantly improved the clinical indices, however biochemical parameters did not change after the treatment. Conclusion:the association of hypertension with periodontitis through local salivary and GCF mediators might be possible in disease process.

Conditions

Interventions

PROCEDURE

Scaling and root planing

Each tooth with inflammation symptoms was cleaned with scalers, curettes and ultrasonic devices routinely.

Sponsors & Collaborators

  • Gazi University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
39 Years
Max Age
58 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-02
Primary Completion
2018-03-30
Completion
2018-06-25

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05741970 on ClinicalTrials.gov