Liver Cirrhosis Network Cohort Study

Summary

Liver Cirrhosis Network (LCN) Cohort Study is an observational study designed to identify risk factors and develop prediction models for risk of decompensation in adults with liver cirrhosis. LCN Cohort Study involves multiple institutions and an anticipated 1200 participants. Enrolled participants will have study visits every 6 months (180 days), with opportunities to complete specific visit components via telehealth or remotely. Visits will include collection of questionnaire data and the in-person visits will include questionnaires, physical exams, imaging, and sample collection.

Conditions

• Cirrhosis
• Cirrhosis, Liver
• Cirrhosis Early
• Cirrhosis Due to Hepatitis B
• Cirrhosis Advanced
• Cirrhosis Infectious
• Cirrhosis Alcoholic
• Cirrhosis, Biliary
• Cirrhosis Cryptogenic
• Cirrhosis Due to Hepatitis C
• Cirrhosis Due to Primary Sclerosing Cholangitis
• Autoimmune Hepatitis

Sponsors & Collaborators

• The Cleveland Clinic

  collaborator OTHER

• Columbia University

  collaborator OTHER

• Weill Medical College of Cornell University

  collaborator OTHER

• Duke University

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• University of Miami

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• University of California, San Diego

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• LAC+USC Medical Center

  collaborator OTHER

• Virginia Commonwealth University

  collaborator OTHER

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  collaborator NIH

• National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  collaborator NIH

• National Cancer Institute (NCI)

  collaborator NIH

• University of Southern California

  collaborator OTHER

• Central Virginia Veterans Healthcare System

  collaborator UNKNOWN

• Northwestern University

  lead OTHER

Principal Investigators

• Abigail Smith · Northwestern University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-11-18

Primary Completion

2030-10-24

Completion

2030-10-24

Countries

• United States

Study Locations