MedTrace Logo

Prospective Studies on Immunopathogenesis of Liver Fibrosis

NCT04943978 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2021-06-29

No results posted yet for this study

Summary

The immune system is thought to play a key role in the development of liver inflammation and subsequent liver fibrosis or cirrhosis.

In the case of viral hepatitis and autoimmune hepatitis, for example, numerous studies have focused on the acquired antigen-specific immunity. However, the liver is the site of increased occurrence of the components of the innate immune response (NK and NKT cells) and, in contrast to T cells, these T cells, these do not require antigen presentation.

Therefore, the present study was designed to determine which cellular components of the (NK, NKT, dendritic cells, macrophages) or the acquired immune response (CD4, CD8) or which network of immune cells is involved in the immunopathogenesis of progressive liver inflammation or the development of liver fibrosis.

The aim is to identify lymphocyte populations that exhibit either prognostically favorable or unfavorable characteristics. This should allow conclusions to be drawn for a more targeted and individualized therapy of the respective chronic liver diseases.

Conditions

Interventions

OTHER

just observational blood and liver sampling

Sponsors & Collaborators

  • University of Regensburg

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-02-01
Primary Completion
2023-01-31
Completion
2026-01-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04943978 on ClinicalTrials.gov