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Bartonella in Liver Transplant Patients

NCT02595710 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 3

Last updated 2022-03-02

No results posted yet for this study

Summary

Approximately 20 volunteers who have received a liver transplant and have been diagnosed with cryptogenic cirrhosis will be included in this study. Blood, skin and urine samples will be analyzed for Bartonella spp..

Conditions

  • Cryptogenic Cirrhosis
  • Cryptogenic Chronic Hepatitis

Interventions

OTHER

skin punch biopsy collection

Four-mm skin biopsies from non-lesional skin will be acquired from the patients, processed using our published techniques with Bartonella biomarkers, and imaged using confocal microscopy.

OTHER

Blood collection

Blood will be tested for presence of Bartonella DNA and Bartonella antibodies using the Alpha Proteobacterium Growth Medium (BAPGM) multi-platform testing, including liquid culture, enriched agar plating and molecular techniques.Blood smears will be analyzed for presence of intra-erythrocytic Bartonella spp. by immunostaining.

OTHER

Urine sample collection

Urine samples will be collected and analyzed for Bartonella spp specific microRNAs.

Sponsors & Collaborators

Principal Investigators

  • Marna E Ericson, phd · University of Minnesota

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2020-12-01
Completion
2021-12-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02595710 on ClinicalTrials.gov