Immune-supportive Diet and Gut Permeability in Allergic Children

Summary

Peanut and nut allergy can be life threatening. Some patients have very low threshold levels (i.e. the amounts of peanut and nuts to which the patients react), others react to higher doses. The reasons for these differences in threshold are not well understood. Patients with peanut and nut allergy often suffer from other allergic diseases (atopic dermatitis, hay fever and asthma). A disturbed gut microbiota composition and an increased gut permeability may explain the development of allergic disease. We hypothesize that increased gut permeability is related to low threshold levels to peanuts or nuts. In addition, as it is known that nutrition can influence our gut permeability, we also hypothesize that a healthful immune-supportive diet restores gut permeability and alleviates symptoms.

Therefore, the purpose of the study is to study in peanut and nut allergic children:

1. the relationship between gut permeability and threshold levels to peanut or nuts;
2. the effect of an immune-supportive diet on gut permeability, gut microbiome composition, coexisting allergic symptoms and quality of life

Conditions

• Peanut Allergy
• Nut Allergy

Interventions

OTHER

Immune-supportive diet

The intervention includes a immune-supportive diet over a period of 4 months

OTHER

Standard care

Standard care: Peanut or nut free diet

Sponsors & Collaborators

• Ekhaga foundation

  collaborator UNKNOWN

• Rijnstate Hospital

  collaborator OTHER

• Noordwest Ziekenhuisgroep

  collaborator OTHER

• Erasmus Medical Center

  collaborator OTHER

• Wageningen University

  collaborator OTHER

• Amsterdam UMC

  collaborator OTHER

• Utrecht Institute for Pharmaceutical Sciences

  collaborator OTHER

• Diakonessenhuis, Utrecht

  collaborator OTHER

• Deventer Ziekenhuis

  collaborator OTHER

• Harvard University

  collaborator OTHER

• Onze Lieve Vrouwe Gasthuis

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

3 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-09-08

Primary Completion

2026-06-30

Completion

2027-06-30

Countries

• Netherlands

Study Locations