MedTrace Logo

Boiled Peanut Oral Immunotherapy for the Treatment of Peanut Allergy: a Pilot Study

NCT02149719 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 47

Last updated 2024-03-29

Study results available
· View outcomes & findings →

Summary

Peanut allergy is increasingly common, especially in countries such as UK and Australia. There is currently no accepted routine clinical therapy to cure peanut allergy. Recently studies have looked at desensitising people with peanut allergy by giving them small daily doses of roasted peanut. Although this therapy works for some people, its effects are not generally long lasting and it is associated with many side effects during protocol, resulting in a significant rate of drop-outs.

Pilot data suggests that boiled peanut is less immunogenic than roasted peanut, and may therefore provide a safer way of inducing desensitisation in patients who are allergic to roasted peanut, by first inducing tolerance to boiled peanut.

Study hypothesis: Increasing doses of boiled peanut can induce desensitisation to roasted peanut, in peanut-allergic individuals.

Conditions

  • IgE Mediated Peanut Allergy

Interventions

OTHER

Desensitisation using boiled peanut

OTHER

Desensitisation using boiled peanut (deferred start)

Sponsors & Collaborators

  • University of Sydney

    collaborator OTHER

  • National Institute for Health Research, United Kingdom

    collaborator OTHER_GOV

  • Imperial College London

    lead OTHER

Principal Investigators

  • Dianne E Campbell, FRACP PhD · The Children's Hospital at Westmead, Australia

  • Sam Mehr, FRACP · The Children's Hospital at Westmead, Australia

  • Paul J Turner, FRACP PhD · Imperial College London

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
8 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2020-11-30
Completion
2022-05-12

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02149719 on ClinicalTrials.gov