Integrated Approaches to Food Allergen and Allergy Risk Management

Summary

Patients with history of a food allergy to hazelnut, walnut or celeriac will undergo food provocation with a dose of the allergenic food to which 5% of the respective food allergic population (ED05) has been calculated to respond with allergic reactions (single shot study).

In patients with a hazelnut or peanut allergy a double-blind placebo controlled food challenge with cookies containing either placebo or hazelnut and peanut respectively will be performed to determine threshold levels eliciting an allergic reaction. The results for threshold levels determined by cookie matrix will be compared to the results gained from the EuroPrevall project (matrix comparison study).

In patients with a walnut allergy double-blind placebo controlled provocation with walnut will be combined with the intake of proton pump inhibitor (PPI) or with placebo to assess the impact of PPI on the threshold level and on the clinical manifestation.

Conditions

• Food Allergy

Interventions

OTHER

food

food provocation, skin testing, blood sampling

Sponsors & Collaborators

• Cork University Hospital

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

  collaborator OTHER

• University of Nebraska Lincoln

  collaborator OTHER

• Region Hovedstadens Apotek

  collaborator OTHER_GOV

• Servicio Madrileño de Salud, Madrid, Spain

  collaborator OTHER

• Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

  collaborator OTHER

• University of Zurich

  lead OTHER

Principal Investigators

• Clare Mills, Coordinator · University Manchester

Study Design

Allocation

NA

Purpose

OTHER

Masking

DOUBLE

Model

SINGLE_GROUP

Eligibility

Min Age

5 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-11-30

Primary Completion

2017-02-28

Completion

2017-02-28

Countries

• Switzerland

Study Locations