CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.

Summary

Cardiac dysfunction is common following hospital admission with sepsis and one of the most frequent causes for readmissions to hospital, however underlying mechanisms by which this might occur are unclear. The CONDUCT-ICU investigators will conduct a pilot, cohort study, characterizing cardiac function in ICU survivors of sepsis using a combination of CMR imaging, biomarkers and patient reported outcome measures to investigate mechanisms of cardiac dysfunction following sepsis. Comparisons will be made to that of the general population.

Conditions

• Heart Failure
• Myocarditis
• Sepsis
• Septic Shock

Interventions

DIAGNOSTIC_TEST

CMR

CMR Imaging 6-10 weeks post hospital discharge.

DIAGNOSTIC_TEST

hs-troponin

Biomarker of myocardial injury

DIAGNOSTIC_TEST

NT-pro BNP

Biomarker for heart failure

DIAGNOSTIC_TEST

CRP

Acute phase inflammatory marker

DIAGNOSTIC_TEST

IL1-B

Inflammatory biomarker

DIAGNOSTIC_TEST

IL-6

Inflammatory Biomarker

DIAGNOSTIC_TEST

IL-10

Inflammatory Biomarker

DIAGNOSTIC_TEST

TNF-alpha

Inflammatory Biomarker

Sponsors & Collaborators

• NHS Ayrshire and Arran

  collaborator OTHER

• Golden Jubilee National Hospital

  collaborator OTHER_GOV

• University of Glasgow

  collaborator OTHER

• NHS Greater Glasgow and Clyde

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-03-01

Primary Completion

2023-12-31

Completion

2024-02-29

Countries

• United Kingdom

Study Locations