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Changes of Exosomes and Biomarkers in Plasma and Alveolar Lavage Fluid of Patients With Sepsis Complicated With ARDS

NCT05476029 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2022-07-27

No results posted yet for this study

Summary

In this study, serum samples and alveolar lavage fluid from patients with sepsis complicated with ARDS were studied. The differential miRNAs of inflammatory exosomes in patients with sepsis lung injury were screened, and Sestrin2, HO-1 and PPARγ proteins, oxidative stress and inflammatory indexes in serum and alveolar lavage fluid were measured simultaneously, to explore the relationship between HO-1, oxidative inflammatory indexes and metabolic indexes. These results provide an important reference for assisting the management of ARDS disease and predicting the adverse outcomes of sepsis patients with ARDS.

Conditions

  • Sepsis Complicated With ARDS

Interventions

DIAGNOSTIC_TEST

Blood samples and alveolar lavage fluid were collected

Blood samples and alveolar lavage fluid were collected for exosome sorting and identification, differential miRNAs, and analysis of serum oxidation and inflammatory indicators.

Sponsors & Collaborators

  • Tianjin Nankai Hospital

    lead OTHER

Principal Investigators

  • Jianbo Yu, MD,PhD · Tianjin Nankai Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-25
Primary Completion
2023-05-30
Completion
2023-12-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05476029 on ClinicalTrials.gov