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SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU

NCT01378169 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2017-10-17

No results posted yet for this study

Summary

Aim of the study : The primary aim of the investigators study is to highlight the presence of biomarkers (biological indicators of the presence of inflammation or infection) of infectious processes during the systemic inflammatory response (SIRS) allowing, first to discriminate non-infectious inflammation from infectious processes and secondary to determine the microbial pathogen responsive of the infection. For this purpose the investigators will conduct a combinatorial approach of several blood markers including usual markers of inflammation and other blood and cells markers. Expression of small pieces of RNA (miRNA) known to inhibit determined gene expression, will also be analysed in monocytes (a specific group of white blood cells involved in the fist line of defences against microbes.

Study design : For this purpose the investigators will include 300 patients admitted to the intensive care unit with suspicion of infection. Serial blood sample will be take for biological parameters analysis. Efficiency of each single parameters and of different combinations of different markers to determine the presence or absence of infection responsive of clinical inflammation will be studied.

Conditions

  • SIRS
  • Sepsis
  • Severe Sepsis
  • Septic Shock

Sponsors & Collaborators

  • BioMérieux

    collaborator INDUSTRY

  • Institut Pasteur

    collaborator INDUSTRY

  • Assistance Publique - Hôpitaux de Paris

    collaborator OTHER

  • Fondation Hôpital Saint-Joseph

    lead OTHER

Principal Investigators

  • François J Philippart, MD; PhD · Fondation Hôpital Saint-Joseph

Eligibility

Min Age
18 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-01-01
Primary Completion
2013-01-01
Completion
2013-06-01

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01378169 on ClinicalTrials.gov