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The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?

NCT06749483 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-12-30

No results posted yet for this study

Summary

Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.

Conditions

  • Critical Illness
  • Intensive Care Unit Delirium
  • Neurocognitive Deficit
  • Microbiome,immune Function, Critically Ill
  • Infection in ICU
  • Sepsis

Sponsors & Collaborators

  • Friedrich Schiller University of Jena

    collaborator UNKNOWN

  • Jena University Hospital

    lead OTHER

Principal Investigators

  • Johannes Ehler, Priv.-Doz. Dr. med. · Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-27
Primary Completion
2026-06-30
Completion
2026-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06749483 on ClinicalTrials.gov