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Oxidative Monitoring in ICU Patients.

NCT02114853 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2014-04-15

No results posted yet for this study

Summary

Sepsis is common in the ICU and is associated with high mortality that reaches up to 60%, increased duration of hospitalization and additional costs \[1,2\].Early diagnosis and stratification of severity are of great importance in order to timely apply proper and adequate treatment \[3\].

Oxidative stress is implicated in inflammation and sepsis and sepsis severity seems to correlate with increased oxidative stress \[7,8\]. Monitoring of oxidative stress has been done so far with various markers which reflect the different pathways of oxidative stress as is oxidosis of lipids, proteins, nucleic acids; yet the antioxidant capacity of various enzymes and vitamins has been studied \[9\]. However these methods do not reflect oxidative stress as a whole, are time consuming, need special laboratory procedures and are costly.

Oxidation-reduction potential is a new technique that enables bedside assessment of the oxidative status. It is based on measuring the balance of oxidants and reductants in human blood with a simple plasma test that reports results immediately.

Hypothesis

Oxidation-reduction potential, used for oxidative monitoring in ICU patients, might correlate with sepsis severity and may be used in addition to other clinical and/or inflammatory markers to assess severity and possibly prognosis.

Conditions

Sponsors & Collaborators

  • University of Thessaly

    lead OTHER

Principal Investigators

  • Epaminondas Zakynthinos, Prof. · University of Thessaly

  • Maria Karapetsa, MD · University of Thessaly-University Hospital of Larissa,ICU

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2015-01-31
Completion
2016-04-30

Countries

  • Greece

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02114853 on ClinicalTrials.gov