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Adjunctive Probiotics in Chronic Periodontitis

NCT03499184 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2019-03-12

No results posted yet for this study

Summary

This study will assess clinical and microbiological efficacy of probiotics and antibiotics in patients of chronic periodontitis as an adjunctive to scaling and root planing (SRP) in reducing bacterial count and in improving clinical periodontal parameters over the period of 12 weeks.Also the comparison between these adjunctives will be made for clinical assessment clinical periodontal parameters will be taken .these parameters plaque index (PI), gingival index (GI), clinical attachment loss (CAL) and pocket probing depth (PPD) for microbiological assessment plaque sample will be taken, DNA will be extracted and then sample will be processed through quantitative polymerase chain reaction (qPCR) for quantitative analysis of bacterial count of porphyromonas gingivalis.

Conditions

  • Chronic Periodontitis
  • Probiotics

Interventions

DIETARY_SUPPLEMENT

P Flor locally delivered

Locally delivered Lactobacillus reuteri 1.2 CFU per gram

DIETARY_SUPPLEMENT

P Flor systemically administered

Systemically administered Lactobacillus reuteri 1.2 CFU per gram

DRUG

Amoxil 500 mg Oral Capsule

Systemically administered Amoxil 500 mg thrice daily

DRUG

Flagyl 400 mg Tablet

Systemically administered Metronidazole 400 mg twice daily

Sponsors & Collaborators

  • Ziauddin Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-11-01
Primary Completion
2018-09-01
Completion
2018-10-01

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03499184 on ClinicalTrials.gov