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Microbiome Dysfunction in Surgical Intensive Care Unit Survivors

NCT05357170 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 468

Last updated 2025-06-12

No results posted yet for this study

Summary

Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied but may be responsible for persistent systemic inflammation clinically observed in surgical intensive care patients. Therefore, the objective of this project is to investigate the oral and gut microbiome after the acute phase of sepsis, severe trauma injury, cardiopulmonary bypass, and major vascular surgery to compare with 108 age-matched healthy population controls

Conditions

  • Sepsis, Trauma Injury

Interventions

OTHER

Human feces collection

Oral swab and saliva, human feces collection and blood sampling

Sponsors & Collaborators

  • National Institute of General Medical Sciences (NIGMS)

    collaborator NIH

  • University of Florida

    lead OTHER

Principal Investigators

  • Philip Efron, MD · UF COM Department of Surgery

Eligibility

Min Age
18 Years
Max Age
110 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-21
Primary Completion
2027-05-31
Completion
2028-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05357170 on ClinicalTrials.gov