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Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function

NCT03849326 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2023-04-26

No results posted yet for this study

Summary

Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life.

The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in this feeling of chronic fatigue. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology will allow to optimize rehabilitation treatments to decrease the apparition/persistence of chronic fatigue and in fine improve life quality.

Conditions

  • Chronic Fatigue Syndrome
  • Intensive Care Unit
  • Muscle

Interventions

OTHER

Questionnaires

Quality of life Depression Physical pain Social provisions Quality of sleep

BIOLOGICAL

blood test

complete blood count and cytokine concentration

OTHER

Maximal effort test

The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory.

DEVICE

actigraphy

assessment of sleep quality

DEVICE

Neuromuscular evaluation

* The maximum isometric force produced by the knee extensors will be measured on the ergometer * the intensity of muscular electrical activity recorded by surface electromyography * Peripheral nerve stimulation * Transcranial magnetic stimulation * Magnetic resonance imaging (optional)

Sponsors & Collaborators

  • University of Saint-Etienne

    collaborator UNKNOWN

  • Centre Hospitalier Universitaire de Saint Etienne

    lead OTHER

Principal Investigators

  • Jérome MOREL, MD PhD · CHU de Saint Etienne

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-31
Primary Completion
2025-03-31
Completion
2025-04-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03849326 on ClinicalTrials.gov